Introduction: The hyper-catabolic state is a devastating pathophysiological response to severe injury, infection or burns. Nandrolone decanoate (ND) is a potent anabolic steroid have many clinical indications, but not investigated in burn injuries yet. Patients and methods: A prospective randomized control study included 40 burned patients who were treated in Burn unit from burn injuries ranged from 20 to 40%. Both groups are objectively assessed, clinically and laboratory during treatment period till full recovery from burns’ injury. Recall assessment of the drug safety after many years is

Background: Taurine-upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA-377 (miRNA-377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator-activated receptors (PPARs) are components of the nuclear hormone receptor superfamily. PPAR-γ activators stimulate melanogenesis. Interleukin (IL)-17 has been implicated in the pathogenesis of several immunological diseases. This work aimed at detecting the expression levels of lncRNA TUG1, miRNA-377, PPAR-γ, and IL-17 among vitiligo

Background: Data have been accumulating in the past few years that identify vitiligo as a disorder with systemic implications. Results and methods: In this hospital-based, cross-sectional, case–control study, 50 patients with non-segmental vitiligo and 50 age- and sex-matched controls underwent analysis of serum lipid profile, oxidative stress biomarkers and carotid duplex. Hydrogen peroxide (H2O2) and malondialdehyde (MDA) were significantly higher in patients than controls (p-value <.001, <.001, respectively); on the other hand, total antioxidant capacity (TAC) was significantly lower in

Cellular respiration is an important process performed by mitochondria. Nad complex is the major complex involved in this process and one of the main subunits in this complex is the nad7 (nad dehydrogenase subunit 7). In Hordeum vulgare subsp. spontaneum, four nad7 cDNAs are described at 500 mM salinity, 0 h, or control (GenBank accession no. MW433884), after 2 h (GenBank accession no. MW433885), after 12 h (GenBank accession no. MW433886) and after 24 h (GenBank accession no. MW433887). Twenty six RNA editing sites were revealed in positions: C44, C45, C77, C83, C99, C137, C224, C244, C251

Introduction: Cancer is one of the most difficult challenges faced by humanity due to its many associated issues, such as inability to prevent diseases, treatment safety, and high mortality rate. In cancer, a variety of cellular signaling is activated to ensure malignancy transformation, angiogenesis and metastasis. The most efficient signaling pathway in cancer is mitogen-activated protein kinase (MAPK), which controls malignancy and regulates apoptosis. Methods: Four different flavonoid glycosides have been isolated from Pulicaria jaubertii using the phytochemical characterization of hydro

Bio-impedance circuit modeling is a popular and effective non-invasive technique used in medicine and biology to fit the measured spectral impedance data of living or non-living tissues. The variations in impedance magnitude and/or phase at different frequencies reflect implicit biophysical and biochemical changes. Bio-impedance is also used for sensing environmental changes and its use in the agriculture industry is rapidly increasing. In this paper, we review and compare among the fractional-order circuit models that best fit bio-impedance data and the different methods for identifying the

Pulsed wave Doppler ultrasound is commonly used in the diagnosis of cardiovascular and blood flow abnormalities. Doppler techniques have gained clinical significance due to its safety, real-time performance and affordability. This work presents the development of a pulsed wave spectral Doppler module, which was integrated into a reconfigurable ultrasound system. The targeted system adopts a hardware-software partitioning scheme where an FPGA handles the front-end and a PC performs the back-end. Two factors were considered during the design. First, the data transfer rate between hardware and

The spread of epidemics and diseases is known to exhibit chaotic dynamics; a fact confirmed by many developed mathematical models. However, to the best of our knowledge, no attempt to realize any of these chaotic models in analog or digital electronic form has been reported in the literature. In this work, we report on the efficient FPGA implementations of three different virus spreading models and one disease progress model. In particular, the Ebola, Influenza, and COVID-19 virus spreading models in addition to a Cancer disease progress model are first numerically analyzed for parameter

Energy harvesting was and still an important point of research. Batteries have been utilized for a long time, but they are now not compatible with the downsizing of technology. Also, their need to be recharged and changed periodically is not very desirable, therefore over the years energy harvesting from the environment and the human body have been investigated. Three energy harvesting methods which are the Piezoelectric energy harvesters, the Enzymatic Biofuel cells, and Triboelectric nanogenerators (TENGs) are being discussed in the paper. Although Biofuel cells have been investigated for a

Simeprevir sodium (SMV) is one of the antiviral drugs used for the treatment of virus C. The current strategy develops and validates a new eco-concerned tool for its quantification in the pure and pharmaceutical formulations. Sulfonephthalein acid dyes were used for this purpose, applying visible analyses based on ion-pair formation. A linear relation between the absorbed signal and the drug concentration is obtained up to 67.0 μg mL-1 with r2 of 0.9989-0.9999. The measurement is carried out at 410, 415, 410, and 403 nm for bromocresol green, bromoxelenol blue, bromothymol blue, and